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Product Quality

Assessing ingredient quality is an important step when selecting the most suitable ingredients to be used in consumer formulations. Ensuring the right quality-price ratio can ensure the correct positioning of ingredients on offer.

Quantitative assessment of Vitamin K2 MK-7
Pricing of Vitamin K2 MK-7 is based on the quantitative & qualitative amount of pure Vitamin K2 (MK-7) claimed in the product description. This is best analysed by HPLC method using a C18 reversed phase column. This will determine the net content of the various menaquinones (MK). Fermentation produced Vitamin K2 MK-7 invariably has MK’s other than MK-7. On the contrary, K2VITAL®, produced through organic synthesis, only contains Vitamin K2 MK-7:

Vitamin K2 products analysed by C30 reversed phase column (270 nm)

Kappa Bioscience Product

Example of fermentation produced MK-7 product

Quantitative assessment of isomeric (cis/trans) purity of MK-7
Another often overlooked or not well understood aspect during evaluation of various MK-7’s is the quantification of the cis/trans content of the ingredient. Indeed, as well as being quantitative, it is a qualitative indication of the Vitamin K2 MK-7. Only the trans form of the MK-7 is biologically active, while the cis component has no biological activity and as such, should be disregarded in the total Vitamin K2 MK-7 content. Traditionally, in fermentation produced material, both cis & trans are included in the total Vitamin K2 MK-7 content, leading to a wrong conclusion. Since functionality can only be expected from the all-trans content, the consumer could be misled. A high content of all-trans MK-7 indicates a higher quality.


For more information on K2VITAL® Quality, please contact us.